Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetamide | HCID 6580 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 178515890 | HCID 178515890 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | HCID 178514043 | HCID 178514043 | — |
Reaction Steps
To a mixture of 4-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)phenol (58 mg, 0.2 mmol) and sodium hydride (55-65%, 18 mg, 0.4 mmol) in DMF (6 ml), 2-chloroacetamide (19 mg, 0.2 mmol) was added and the mixture was heated to 60° C. for 1 h. Column chromatography on silica using ethyl acetate/methanol as eluent afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07410966B2 |
|---|
| Source dataset | uspto-grants-2008_08 |
|---|
| ORD ID | ord-1dec0bc50e3f4c6eaadb8956c3940b86 |
|---|
| Source note | uspto-grants-2008_08 |
|---|
