HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 6-Bromo-2-[4-(3-morpholin-4-ylpropoxy)phenyl]-3H-imidazo[4,5-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Lithium iodide | HCID 66321 | — |
| Reactant | HCID 178478466 | HCID 178478466 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Product | 6-Bromo-2-[4-(3-morpholin-4-ylpropoxy)phenyl]-3H-imidazo[4,5-b]pyridine | HCID 178419442 | — |
Reaction Steps
A solution of 6-bromo-2-[4-(3-chloropropoxy)phenyl]-3H-imidazo[4,5-b]pyridine (50 mg, 0.14 mmol), lithium iodide (20 mg, 0.15 mmol) and morpholine (0.1 ml, 1.15 mmol) in DMF (5 ml) was heated at 100° C. for 6 h. Column chromatography on silica using methylene chloride/methanol/ammonia as eluent afforded the title compound in almost quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07410966B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-781a4f5b4578488baf414060aa9f1686 |
| Source note | uspto-grants-2008_08 |