HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 178419444, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 178478508 | HCID 178478508 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Solvent | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Product | HCID 178419444 | HCID 178419444 | — |
Reaction Steps
A solution of 6-bromo-2-[4-(2-chloroethoxy)phenyl]-3H-imidazo[4,5-b]pyridine (50 mg, 0.14 mmol), morpholine (0.037 ml, 0.42 mmol) in NMP (5 ml) and N-ethyldiisopropylamine (0.24 ml, 1.4 mmol) was heated at 120° C. for 6 h. Column chromatography on silica using methylene chloride/methanol/ammonia as eluent afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07410966B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-d194298a99f64b8298d10c7f44b69352 |
| Source note | uspto-grants-2008_08 |