6-Chloronicotinic acid → HCID 178515893, compound

Participants

Reaction Conditions

Reaction Steps

Polyphosphoric acid (3 g) was heated to 140° C. and 2,3-diamino-5-bromopyridine (417 mg, 2.22-mmol) and 6-chloronicotinic acid (525 mg, 3.33 mmol) were added. The reaction mixture was stirred overnight at 140° C. After cooling, ice was added and the pH adjusted to 7 with a saturated solution of sodium hydrogen carbonate. A precipitate was formed which was filtered off and washed with ethyl acetate to afford the title compound (341 mg, 53%).

Provenance & Evidence