Sodium Bicarbonate → HCID 10479635, compound

Participants

Reaction Conditions

Reaction Steps

6,7-Dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine (Example 206) (2:9 mg, 7.4 μmol) was dissolved in 48% aqueous HBr (1 ml) and heated at 110° C. for 3 h. whereupon the mixture was neutralized with saturated aqueous NaHCO3 and extracted with EtOAc (5 ml). The organic phase was washed with brine, dried (MgSO4) and evaporated to give a white powder (2.0 mg, 58%).

Provenance & Evidence