HCID 178478272, compound → HCID 69213753, compound

HRID 2218390Notes

Reaction equation

HRID 2218390 reaction equation
[Cl:1][C:2]1[C:3](Cl)=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:25][CH2:24][O:23][CH2:22][CH2:21]4)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1>N1CCOCC1>[Cl:1][C:2]1[C:3]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[C:4]2[NH:10][C:9]([C:11]3[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:21][CH2:22][O:23][CH2:24][CH2:25]4)=[CH:15][CH:16]=3)=[N:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 1

HCID 178478272HCID 178478272, compound

Product 1

HCID 69213753HCID 69213753, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 8083MorpholineSolvent

Conditions

Temperature
180 °C

Procedure

6,7-Dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine (Example 206) (10 mg, 25 μmol) was dissolved in morpholine (0.5 ml) and heated in a microwave oven at 180° C. for 15 min. The excess morpholine was evaporated in vacuo and the oily residue triturated with EtOAc. The crystals formed were collected by filtration and washed with a 1: I EtOAc/n-heptane mixture. This afforded the product as a white powder (5 mg, 44%).

Workup

  1. customThe excess morpholine was evaporated in vacuo
  2. customthe oily residue triturated with EtOAc
  3. customThe crystals formed
  4. filtrationwere collected by filtration
  5. washwashed with a 1

Sources & evidence

ORD record
ord-61052fed7c224f5cb48a70fb58c3d079
Source dataset
uspto-grants-2008_08
Patent number
US07410966B2

Reaction notes

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