2-Fluoroaniline → HCID 178505639, compound

HRID 2218391Notes

Reaction equation

[Cl:1][C:2]1[C:3](Cl)=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:25][CH2:24][O:23][CH2:22][CH2:21]4)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1.[F:27][C:28]1[CH:34]=[CH:33][CH:32]=[CH:31][C:29]=1[NH2:30]>>[Cl:1][C:2]1[C:3]([NH:30][C:29]2[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=2[F:27])=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:21][CH2:22][O:23][CH2:24][CH2:25]4)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

Reactant 2

HCID 95842-Fluoroaniline

HCID 178478272HCID 178478272, compound

Product 1

HCID 178505639HCID 178505639, compoundYield 56%

Procedure

By a procedure similar to that of Example 219 but using 6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine (Example 206) and 2-flouroaniline, the title compound was obtained in 56% yield.

Sources & evidence

ORD record: ord-fdb97e4076cf462b8209bd9d39f77cb0
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07410966B2

Reaction notes

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