反应详情

温度

0 °C

Methyl 4-(2-morpholin-4-ylethoxy)benzoate (Example 206c) (30 g, 110 mmol) was dissolved in conc. sulfuric acid (70 ml) and cooled to 0° C. Nitric acid (d=1.52, 4.7 ml, 110 mmol) was added and the mixture was allowed to assume room temperature within 1 h. The reaction mixture was poured onto an ice water mixture (600 g) whereupon crystals formed. The crystals were collected by filtration and washed with water to give the pure product as a white powder (25 g, 80%).

1. customformed
2. filtrationThe crystals were collected by filtration
3. washwashed with water