反应详情

温度

100 °C

4-(6-Chloro-7-methyl-3H-imidazo[4,5-b]pyridin-2-yl)-2-nitrophenol (Example 248) (105 mg, 0.34 mmol), 4-(2-chloroethyl)morpholine hydrochloride (74 mg, 0.40 mmol) and sodium hydride (29 mg, 1.2 mmol) were dissolved in DMF (13 ml). The reaction mixture was stirred at 100° C. overnight and then quenched with water (5 ml) and evaporated. The residue was dissolved in CH3CN (4 ml) and a drop of TFA and purified by HPLC C18. The appropriate fractions were collected and concentrated in vacuo to afford the subtitle compound (100 mg, 60%).

1. customquenched with water (5 ml)
2. customevaporated
3. dissolutionThe residue was dissolved in CH3CN (4 ml)
4. customa drop of TFA and purified by HPLC C18
5. customThe appropriate fractions were collected
6. concentrationconcentrated in vacuo