Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | HCID 178526538 | HCID 178526538 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,2-Dichlorobenzene | HCID 7239 | — |
| Product | HCID 178526540 | HCID 178526540 | 77% |
Reaction Steps
6,7-Dichloro-2-(4-nitrophenyl)-3H-imidazo[4,5-b]pyridine (0.73 g, 2.4 mmol), aniline (0.70 ml) and a catalytical amount of p-toluenesulfonic acid monohydrate were dissolved in o-dichlorobenzene (4.0 ml) and heated to 180° C. for 5 h. Ethyl acetate and methanol were added, the mixture stirred and the solid filtered off to afford the title compound (0.68 g, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07410966B2 |
|---|
| Source dataset | uspto-grants-2008_08 |
|---|
| ORD ID | ord-f18c32479bd648faae9fcfa565ecfd20 |
|---|
| Source note | uspto-grants-2008_08 |
|---|
