HCID 178492967, compound → HCID 178492966, compound

HRID 2218428Notes

Reaction equation

HRID 2218428 reaction equation
[Cl:1][C:2]1[C:3]([O:20][CH3:21])=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1>CO>[Cl:1][C:2]1[C:3]([O:20][CH3:21])=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 1

HCID 178492967HCID 178492967, compound

Product 1

HCID 178492966HCID 178492966, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-Chloro-7-methoxy-2-(4-nitrophenyl)-3H-imidazo[4,5-b]pyridine (0.56 g, 1.8 mmol) was dissolved in methanol (30 ml). (NH4)2S (20% in water, 5 ml, 15 mmol) was added and the mixture was heated to reflux for 5 h. The methanol was removed under reduced pressure and the resulting precipitate was filtered off and washed with ice-cold water giving 0.486 g (96%) of the subtitle compound.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 5 h
  3. customThe methanol was removed under reduced pressure
  4. filtrationthe resulting precipitate was filtered off
  5. washwashed with ice-cold water giving 0.486 g (96%) of the subtitle compound

Sources & evidence

ORD record
ord-0a05957525e24b8588cbed23ae51bce6
Source dataset
uspto-grants-2008_08
Patent number
US07410966B2

Reaction notes

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