HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-((2R)-2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide → N-[(2S)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-((2R)-2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide | HCID 9826528 | — |
| Reactant | (S)-O-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)hydroxylamine | HCID 14814202 | — |
| Reactant | 2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic acid | HCID 22025663 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[(2S)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide | HCID 10152076 | — |
Reaction Steps
Prepared from (S)-O-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-hydroxylamine and 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid by the procedure described above for N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide: m.p. 116-118° C. (Form II of Compound C); and m.p. 116-118° C. (Form I of Compound C); [α]=+1.77° (c=1.13, methanol). Analysis: Calcd. For: C16H14F3I1N2O4: C, 39.85; H, 2.93; N, 5.81; F, 11.82; I, 26.32. Found: C, 40.01; H, 2.73; N, 5.84; F, 11.45; I, 26.42.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07411001B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-67269d5cdcdc4c99afd9971c86abce5d |
| Source note | uspto-grants-2008_08 |