Hydrochloric Acid → 4-(Phenoxymethyl)-1,3-thiazol-2-amine

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(4-phenoxymethyl-thiazol-2-yl)-acetamide (40 mg, 0.16 mmol) in THF (2 ml) was added 6N HCl (2 ml). The reaction was heated at 60° C. for 3 hours following by stirring at room temperature overnight and then heated at 60° C. for additional 3 hours. The solution was concentrated to afford 4-phenoxymethyl-thiazol-2-ylamine (HCl salt) as a brown viscous oil (35 mg, 90% ). LC/MS m/z 207.09 (M+1)+; HPLC Rt: 1.137 min

Provenance & Evidence