Sodium Methoxide → HCID 10584352, compound

HRID 221856Notes

Reaction equation

HRID 221856 reaction equation
[Cl:1][C:2]1[C:3](=[O:12])[N:4]([CH2:9][O:10][CH3:11])[N:5]=[CH:6][C:7]=1Cl.[CH3:13][O-:14].[Na+]>CO>[Cl:1][C:2]1[C:3](=[O:12])[N:4]([CH2:9][O:10][CH3:11])[N:5]=[CH:6][C:7]=1[O:14][CH3:13]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 123518344,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one

Product 1

HCID 10584352HCID 10584352, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3one (500 mg, 2.39 mmol) in methanol (12 mL) at room temperature was added sodium methoxide (258 mg, 4.78 mmol). After stirred for 2 h, the reaction was concentrated. To this residue was added water (20 mL), then extracted with CH2Cl2 (2×50 mL). The combined organic layer was dried (Na2SO4) and concentrated to give 480 mg (98%) 4-chloro-5-methoxy-2-methoxymethyl-2H-pyridazin-3-one.

Workup

  1. concentrationthe reaction was concentrated
  2. additionTo this residue was added water (20 mL)
  3. extractionextracted with CH2Cl2 (2×50 mL)
  4. dry with materialThe combined organic layer was dried (Na2SO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-cda13ed56ebf405398703678ec35ac9c
Source dataset
uspto-grants-2012_06
Patent number
US08207168B2

Reaction notes

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