Hydrochloric Acid → HCID 68978225, compound

Participants

Reaction Steps

trans-2-(4-Methyl-2-oxo-pyrrolidin-1-yl)-cyclohexanecarboxylic acid ethyl ester (395 mg) was dissolved in absolute THF (15 ml) and 1 N lithium hydroxide solution (5.12 ml) was added. The resulting mixture was refluxed over night. The reaction mixture was cooled to room temperature and then HCl conc. (1.80 ml) was added (pH=2). The mixture was evaporated and then diluted with toluene and evaporated to remove the water. The residue was purified by flash chromatography (AcOEt/MeOH 85/15) to give the product as a 1:1 mixture of epimers as light yellow foam (435 mg). MS (ESI): 224.3 (M+H+−).

Provenance & Evidence