HCID 69031216, compound → HCID 11593606, compound

Participants

Reaction Steps

To a solution of trans-[2-(4-methyl-2-oxo-pyrrolidin-1-yl)-cydohexyl]-carbamic acid benzyl ester (34 mg) in absolute ethanol (4.0 ml) was added 10% Pd on charcoal (5 mg). A hydrogen atmosphere was introduced by repeated evacuation/gas introduction. The suspension was vigorously stirred over night. The catalyst was removed by filtration through dicalite and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography (CH2Cl2/MeOH/NH3 93/7/0.5) to give the product as a 1:1 mixture of epimers as a colorless liquid (15 mg). MS (ESI): 197.3 (M+H+).

Provenance & Evidence