Dibenzosuberone → HCID 59770268, compound

HRID 2218631Notes

Reaction equation

HRID 2218631 reaction equation
[CH2:1]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:9](=O)[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2]1.[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:24]=[C:25]([O:27][CH3:28])[CH:26]=1)[CH:22]=O>>[CH3:28][O:27][C:25]1[CH:24]=[C:21]([CH:20]=[C:19]([O:18][CH3:17])[CH:26]=1)[CH:22]=[C:9]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=2[CH2:1][CH2:2][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:8]1=2

Participants

3

Reactant 2

HCID 14589DibenzosuberoneHCID 817473,5-Dimethoxybenzaldehyde

Product 1

HCID 59770268HCID 59770268, compoundYield 41%

Procedure

Following procedures essentially as described in Preparation 5 and Example 28, above, and using dibenzosuberone (2.00 g, 10.29 mmol) and 3,5-dimethoxybenzaldehyde (1.71 g, 10.29 mmol), affords 1.43 g (41%) of the title compound as a yellow foam. 1H-NMR (CDCl3) δ 2.79-3.64 (br m, 4H), 3.55 (s, 6H), 6.20 (d, 2H), 6.25 (t, 1H), 6.72 (s, 1H), 7.06-7.30 (m, 7H), 7.48 (m, 1H); HPLC shows 99% purity.

Workup

  1. customas described in Preparation 5 and Example 28

Sources & evidence

ORD record
ord-510120ac9fe148d4b530f4fe51d82001
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

Loading…