2-Propanesulfonyl chloride → HCID 59770264, compound

HRID 2218643Notes

Reaction equation

HRID 2218643 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH:24]([S:27](Cl)(=[O:29])=[O:28])([CH3:26])[CH3:25]>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH:23][S:27]([CH:24]([CH3:26])[CH3:25])(=[O:29])=[O:28])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 59769897HCID 59769897, compound

Product 1

HCID 59770264HCID 59770264, compoundYield 22%

Procedure

Following procedures essentially as described in Example 90, 3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylamine and isopropylsulfonyl chloride gives the title compound in 22% yield as a white solid, mp 187.7° C. 1H NMR (CDCl3) δ 1.28 (d, 6H), 2.80-3.60 (br m, 5H), 6.47 (s, 1H), 6.75-7.50 (m, 13H); MS (ES) 426 (M+Na), 402 (M−H). HPLC shows 94% purity.

Sources & evidence

ORD record
ord-6ba4f7fe84c44ed9942c1596ba1f0206
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

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