1-Butanesulfonyl chloride → HCID 59769889, compound

HRID 2218650Notes

Reaction equation

HRID 2218650 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:24]([S:28](Cl)(=[O:30])=[O:29])[CH2:25][CH2:26][CH3:27]>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:22]=[CH:21][C:20]([NH:23][S:28]([CH2:24][CH2:25][CH2:26][CH3:27])(=[O:30])=[O:29])=[CH:19][CH:18]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 754301-Butanesulfonyl chlorideHCID 59769900HCID 59769900, compound

Product 1

HCID 59769889HCID 59769889, compoundYield 63%

Procedure

Following procedures essentially as described in Example 90, 4-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylamine (100 mg, 0.336 mmol) and 1-butanesulfonyl chloride (158 mg, 1.01 mmol) affords 88 mg (63%) of the title compound as a yellow oil. MS (ES) 440 (M+Na), 416 (H); HPLC shows 98% purity.

Sources & evidence

ORD record
ord-bcf1bf4dc30e47a3a117e9b955b407d1
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

Loading…