1-Propanesulfonyl chloride, 2-methyl- → HCID 59770259, compound

HRID 2218651Notes

Reaction equation

HRID 2218651 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH3:24][CH:25]([CH3:31])[CH2:26][S:27](Cl)(=[O:29])=[O:28]>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH:23][S:27]([CH2:26][CH:25]([CH3:31])[CH3:24])(=[O:29])=[O:28])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 1822361-Propanesulfonyl chloride, 2-methyl-HCID 59769897HCID 59769897, compound

Product 1

HCID 59770259HCID 59770259, compoundYield 21.4%

Procedure

Following procedures essentially as described in Example 90, 3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylamine (50 mg, 0.168 mmol) and 2-methyl-propane-1-sulfonyl chloride (53 mg, 0.336 mmol) (prepared as described in Quast, H., Synthesis (1974), (7), 489-90) affords 15 mg (21%) of the title compound as a brown oil. MS (ES) 435 (M+NH4), 416 (M−H); HPLC shows 100% purity.

Sources & evidence

ORD record
ord-3a1ffd1a7e3346c6b8d0cf1aaa6441f6
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

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