Dimethylsulphamoyl chloride → HCID 59770104, compound

HRID 2218652Notes

Reaction equation

[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH3:24][N:25]([CH3:30])[S:26](Cl)(=[O:28])=[O:27]>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH:23][S:26](=[O:28])(=[O:27])[N:25]([CH3:30])[CH3:24])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 59769897HCID 59769897, compound

Product 1

HCID 59770104HCID 59770104, compoundYield 68%

Procedure

Following procedures essentially as described in Example 90, 3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylamine (100 mg, 0.336 mmol) and dimethylsulfamoyl chloride (144 mg, 1.01 mmol) affords 92 mg (68%) of the title compound as a yellow oil. MS (ES) 427 (M+Na), 403 (M−H); HPLC shows 93% purity.

Sources & evidence

ORD record: ord-6649c568070d47efa6895ac24cf143a1
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07411072B2

Reaction notes

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