Acetyl chloride → HCID 59770335, compound

HRID 2218654Notes

Reaction equation

HRID 2218654 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:24](Cl)(=[O:26])[CH3:25]>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:26])[CH3:25])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 59769897HCID 59769897, compound

Product 1

HCID 59770335HCID 59770335, compoundYield 25%

Procedure

Following procedures essentially as described in Example 90, 3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylamine and acetyl chloride give the title compound in 25% yield as a white solid. 1H NMR (CDCl3) δ 2.12 (s, 3H), 2.76-3.61 (br m, 4H), 6.71 (d, 1H), 6.75 (s, 1H), 6.96-7.50 (m, 13H); MS (ES) 340 (M+H). HPLC shows 100% purity.

Sources & evidence

ORD record
ord-b2c4be52853a47a7b598e1fe07ee5e62
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

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