Aluminium lithium hydride → HCID 59770289, compound

Participants

Reaction Steps

Dissolve 1.0 g (3.25 mmol) of the corresponding nitrile (prepared as described in Example 81) in diethyl ether (70 mL). Add lithium aluminum hydride (250 mg, 6.6 mmol) and stir at room temperature for 3 h. Quench the reaction by adding 8 drops water, 8 drops 5N NaOH and 16 drops water. Filter the inorganic solids and wash with ether. After drying (MgSO4) and concentration, the title compound was obtained in 98% yield as a colorless oil, MS (ES) 312 (N+1). HPLC shows 98% purity.

Provenance & Evidence