3-Methylsulfonylaminophenylboronic acid → HCID 68937148, compound

Participants

Reaction Steps

Following procedures essentially as described in Example 219, below, and using 4-[2-(5-bromomethylene-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-2-yloxy)-ethyl]-morpholine (220 mg, 0.53 mmol) and 3-methanesulfonamidophenylboronic acid (125 mg, 0.58 mmol). Purification on silica gel eluting with EtOAc then EtOAc/1% MeOH/NH3, gave 57 mg of pure E-isomer. MS (ES)505 (M+1), 503(M−1). HPLC shows 92% purity at t=1.79 min.

Provenance & Evidence