3-Methylsulfonylaminophenylboronic acid → N-[3-(1,9-Difluoro-10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenyl]-methanesulfonamide

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Reaction Steps

Following procedures essentially as described in Example 219, below, and using 3-methanesulfonamidophenyl boronic acid (592 mg, 2.75 mmol) and 5-bromomethylene-1,9-difluoro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (803 mg, 2.75 mmol), provides 1.52 g of the title compound crude product. The crude product is purified using column chromatography (15% EtOAc/hexane to 30% EtOAc/hexane) to give 690 mg (67%) white solid. MS (ES) 410 (M−1). HPLC (ISO90-10M) shows 92% purity at t=2.64 min.

Provenance & Evidence