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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 221870Generated: October 25, 2026

4-Bromo-2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride → 4-bromo-N-(2-morpholin-4-yl-ethyl)-2-trifluoromethoxy-benzene sulfonamide

https://huagongshe.com/reaction/221870

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-2-(Trifluoromethoxy)Benzene-1-Sulfonyl ChlorideHCID 2736421—
Reactant4-bromo-2-methyl-N-(2-morpholin-4-yl-ethyl)benzene-sulfonamideHCID 59557932—
Product4-bromo-N-(2-morpholin-4-yl-ethyl)-2-trifluoromethoxy-benzene sulfonamideHCID 6736444—

Reaction Steps

The title compound was prepared in the same manner as described for 4-bromo-2-methyl-N-(2-morpholin-4-yl-ethyl)benzene sulfonamide, replacing 4-bromo-2-methyl-benzene sulfonyl chloride with 4-bromo-2-trifluoromethoxybenzene sulfonyl chloride. 1H-NMR (DMSO-d6) δ 7.88 to 7.77 (m, 4H), 3.43 (t, J=4.2 Hz, 4H), 2.99 to 2.97 (broad s, 2H), 2.29 to 2.20 (m, 6H); MS LC-MS [M+H]+=433 & 435, RT=2.03 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08207166B2
Source datasetuspto-grants-2012_06
ORD IDord-e2ec11ffde9143af841a37865b352109
Source noteuspto-grants-2012_06