HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride → 4-bromo-N-(2-morpholin-4-yl-ethyl)-2-trifluoromethoxy-benzene sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride | HCID 2736421 | — |
| Reactant | 4-bromo-2-methyl-N-(2-morpholin-4-yl-ethyl)benzene-sulfonamide | HCID 59557932 | — |
| Product | 4-bromo-N-(2-morpholin-4-yl-ethyl)-2-trifluoromethoxy-benzene sulfonamide | HCID 6736444 | — |
Reaction Steps
The title compound was prepared in the same manner as described for 4-bromo-2-methyl-N-(2-morpholin-4-yl-ethyl)benzene sulfonamide, replacing 4-bromo-2-methyl-benzene sulfonyl chloride with 4-bromo-2-trifluoromethoxybenzene sulfonyl chloride. 1H-NMR (DMSO-d6) δ 7.88 to 7.77 (m, 4H), 3.43 (t, J=4.2 Hz, 4H), 2.99 to 2.97 (broad s, 2H), 2.29 to 2.20 (m, 6H); MS LC-MS [M+H]+=433 & 435, RT=2.03 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207166B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-e2ec11ffde9143af841a37865b352109 |
| Source note | uspto-grants-2012_06 |