(4-Methanesulfonamidophenyl)boronic acid → N-[4-(1-Chloro-10,11-dihydro-dibenzo[a,d]cyclohepten-5ylidenemethyl)-phenyl]-methanesulfonamide

Participants

Reaction Steps

Following procedures essentially as described in Example 219, below, and using 5-bromomethylene-1-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (100 mg, 0.313 mmol) and 4-methanesulfonylaminophenylboronic acid (74 mg, 0.344 mmol), affords 55 mg (43%) of a mixture of geometric isomers of the title compound as a brown oil. MS (ES) 408 (M−H); HPLC shows 96% purity.

Provenance & Evidence