HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-hydroxyphenyl)boronic Acid → HCID 68942661, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-hydroxyphenyl)boronic Acid | HCID 2734359 | — |
| Reactant | 5-bromomethylene-1-chloro-10,11dihydro-5H-dibenzo[a,d]cycloheptene | HCID 68891389 | — |
| Product | HCID 68942661 | HCID 68942661 | — |
Reaction Steps
Following procedures essentially as described in Example 219, below, and using 5-bromomethylene-1-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (100 mg, 0.313 mmol) and 3-hydroxyphenylboronic acid (47 mg, 0.344 mmol) affords 8 mg (8%) of the Z-isomer of the title compound (MS (ES) 331 (M−H). HPLC shows 95% purity. Continue to elute and isolate 27 mg (26%) of the E-isomer of the title compound, MS (ES) 331 (M−H). HPLC shows 97% purity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07411072B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-81c24297720c4e39a904068642536013 |
| Source note | uspto-grants-2008_08 |