HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxyphenylboronic acid → 4-(1-Chloro-10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxyphenylboronic acid | HCID 2734360 | — |
| Reactant | 5-bromomethylene-1-chloro-10,11dihydro-5H-dibenzo[a,d]cycloheptene | HCID 68891389 | — |
| Product | 4-(1-Chloro-10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenol | HCID 68935582 | — |
Reaction Steps
Following procedures essentially as described in Example 219, below, and using 5-bromomethylene-1-chloro-10,11dihydro-5H-dibenzo[a,d]cycloheptene (100 mg, 0.313 mmol) and 4-hydroxyphenylboronic acid (47 mg, 0.344 mmol), affords 84 mg (81%) of a mixture of geometric isomers of the title compound as a brown oil. MS (ES) 331 (M−H); HPLC shows 97% purity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07411072B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-1b14c271208b42e68e05c26ca6079e3a |
| Source note | uspto-grants-2008_08 |