p-Bromobenzenesulfonyl chloride → 4-bromo-N-(2-morpholin-4-ylethyl)benzenesulfonamide

HRID 221871Notes

Reaction equation

HRID 221871 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)(=[O:10])=[O:9])=[C:4](C)[CH:3]=1.BrC1C=CC(S(Cl)(=O)=O)=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 595579324-bromo-2-methyl-N-(2-morpholin-4-yl-ethyl)benzene-sulfonamide

Product 1

HCID 43451234-bromo-N-(2-morpholin-4-ylethyl)benzenesulfonamide

Procedure

The title compound was prepared in the same manner as described for 4-bromo-2-methyl-N-(2-morpholin-4-yl-ethyl)benzene sulfonamide, replacing 4-bromo-2-methyl-benzene sulfonyl chloride with 4-bromobenzene sulfonyl chloride. 1H-NMR (DMSO-d6) δ 7.81 to 7.68 (m, 4H), 7.66 (broad s, 1H), 3.46 (t, J=4.8 Hz, 4H), 2.85 (t, J=6.6 Hz, 2H), 2.28 to 2.21 (m, 6H); MS LC-MS [M+H]+=349 & 351, RT=1.34 min.

Sources & evidence

ORD record
ord-711bee3490ba489f957f1013366f1556
Source dataset
uspto-grants-2012_06
Patent number
US08207166B2

Reaction notes

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