Ethyl orthoformate → HCID 59770553, compound

Participants

Reaction Steps

Dissolve 2-amino-4-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenol (see Example 63) (60 mg, 0.191 mmol) in triethylorthoformate (3 mL) and heat to reflux for 4.5 h. Cool to room temperature and concentrate in-vacuo to a brown oil. Chromatograph on 10 g silica gel eluting with 5% to 25% ethyl acetate/hexanes to afford 52 mg (84%) of the title compound as a colorless oil; MS (ES) 324 (M+H), 322 (M−H), HPLC shows 94% purity.

Provenance & Evidence