4-Bromo-3,5-dimethyl-1,2-oxazole → 4-[2-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenyl]-3,5-dimethyl-isoxazole

Participants

Role	Name	HCID	Charge
Reactant	4-Bromo-3,5-dimethyl-1,2-oxazole	HCID 318421	—
Reactant	2-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylboronic acid	HCID 59770265	—
Product	4-[2-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenyl]-3,5-dimethyl-isoxazole	HCID 59770031	2%

Reaction Steps

Following procedures essentially as described in Example 225 and using 2-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylboronic acid (100 mg, 307 mmol) and 4-bromo-3,5-dimethylisoxazole (81 mg, 0.460 mmol), provides the title compound in 2% yield. MS (ES) 378 (M+H); HPLC shows 94% purity.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07411072B2
Source dataset	uspto-grants-2008_08
ORD ID	ord-a1260f9f7d7245f888524c3655739354
Source note	uspto-grants-2008_08