(3-hydroxyphenyl)boronic Acid → HCID 57736644, compound

Participants

Reaction Steps

Following procedures essentially as described in Example 219, combine 11-bromomethylene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (250 mg, 0.87 mmol) and (3-hydroxyphenyl) boronic acid (133 mg, 0.96 mmol). Purify to provide product 166 mg (63%) as an off-white solid. LC/MS: 300.1 (M+H). 1H NMR (DMSO, 400 MHz): δ9.22 (s,1H), 8.40 (d,1H), 7.49 (d,1H), 7.34 (d,1H), 7.24 (d,1H), 7.21 (d,3H), 7.15 (s,1H), 7.04 (t,1H), 6.92 (d,1H), 6.90 (d,1H), 6.52 (d,1H), 6.40-6.42 (m,2H), 3.4-2.8 (m,4H).

Provenance & Evidence