HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 3-(6H-Dibenzo[b,e]oxepin-1-ylidenemethyl)-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Tin tetrachloride dihydrate | HCID 85782573 | — |
| Reactant | 3-Nitro-benzylidene-6,11-dihydro-dibenzo[b,e]oxepine | HCID 86603984 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(6H-Dibenzo[b,e]oxepin-1-ylidenemethyl)-phenylamine | HCID 86603983 | 56% |
Reaction Steps
Dissolve 11-(3-Nitro-benzylidene-6,11-dihydro-dibenzo[b,e]oxepine (200 mg) in ethanol (10 mL) add tin chloride dihydrate (680 mg) and reflux for 5 h. Concentrate the reaction in vacuo, re-dissolve in ethyl acetate and wash with 1N sodium hydroxide solution. Separate the layers wash with brine and dry over sodium sulfate. Purity using filter chromatography eluting with 10% ethyl acetate:toluene to give 60 mg of product (56% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07411072B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-2cffb80652e44e01aaa6a3839092257b |
| Source note | uspto-grants-2008_08 |