3-Nitrophenylboronic Acid → HCID 59770242, compound

Participants

Reaction Steps

Following procedures essentially as described in Example 230, 11-bromomethylene-4-methoxy-6,11-dihydro-dibenzo[b,e]oxepine is combined with m-nitrophenyl boronic acid. The pure E isomer is isolated by recrystallization with hexanes and diethyl ether to give 311 mg of product (33% yield). 1H NMR (400 MHz, CDCl3) δ 7.979-7.949 (d, 1H), 7.874 (s, 1H), 7.509-7.491 (d, 1H), 7.365-7.324 (t, 1H), 7.305-7.237 (m, 2H), 7.204-7.162 (t, 1H), 7.123-7.100 (d, 1H), 6.992-6.912 (m, 3H), 6.864-6.840 (d, 1H), 5.75 (broad s, 1H), 5.19 (broad s, 1H), 3.84 (s, 3H).

Provenance & Evidence