Methanesulfonyl chloride → HCID 69269479, compound

HRID 2218735Notes

Reaction equation

HRID 2218735 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[O:9][CH2:10][C:11]3[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=3[C:13](=[CH:14][C:15]3[CH:16]=[C:17]([NH2:21])[CH:18]=[CH:19][CH:20]=3)[C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:8]2[O:9][CH2:10][C:11]3[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=3[C:13](=[CH:14][C:15]3[CH:16]=[C:17]([NH:21][S:27]([CH3:26])(=[O:29])=[O:28])[CH:18]=[CH:19][CH:20]=3)[C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 68936914HCID 68936914, compound

Product 1

HCID 69269479HCID 69269479, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Following procedures essentially as described in Example 90, the title compound is prepared from 3-(4-Methoxy-6H-dibenzo[b,e]oxepin-11-ylidenemethyl)-phenylamine and methanesulfonyl chloride. Flash chromatography eluting with 5 to 10 to 20% ethyl acetate:toluene provides 198 mg product (60% yield) of the title final product.

Workup

  1. washFlash chromatography eluting with 5 to 10 to 20% ethyl acetate

Sources & evidence

ORD record
ord-fd4a0a040c3846f689198de069003440
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

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