HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoamyl Nitrite → Methyl 5-(2-phenylethyl)-4-thiazolecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoamyl Nitrite | HCID 8053 | — |
| Reactant | HCID 56763068 | HCID 56763068 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 5-(2-phenylethyl)-4-thiazolecarboxylate | HCID 59770291 | 55% |
Reaction Steps
Reflux one equiv of 2-amino-5-phenethyl-thiazole-4-carboxylic acid methyl ester and 3 equiv of isoamyl nitrite in THF (0.13M) for 3 h. Evaporate volatile components to give 55% yield of title compound. BPLC (GRAD80-100M) t=2.410 (99%). MS (APCI): 248 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07411072B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-cb09266c31174053bd53c45a82e4c9dd |
| Source note | uspto-grants-2008_08 |