Sodium Hydroxide → HCID 59770316, compound

HRID 2218773Notes

Reaction equation

HRID 2218773 reaction equation
C([O:3][C:4](=[O:32])[C:5](=[C:17]1[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[CH2:21][CH2:20][C:19]2[CH:28]=[CH:29][CH:30]=[CH:31][C:18]1=2)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[CH:7]=1)C.[OH-].[Na+]>C(O)C>[CH:27]1[C:22]2[CH2:21][CH2:20][C:19]3[CH:28]=[CH:29][CH:30]=[CH:31][C:18]=3[C:17](=[C:5]([C:6]3[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[CH:7]=3)[C:4]([OH:32])=[O:3])[C:23]=2[CH:24]=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 59769922HCID 59769922, compound

Product 1

HCID 59770316HCID 59770316, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Treat (10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-(3-methanesulfonylamino-phenyl)-acetic acid ethyl ester with a 50:50 mixture of 1N NaOH and ethanol and heat under reflux conditions for 14 hours. Acidify with 1N HCl and collect the solid by filtration and dry. Purify by reverse phase HPLC to obtain a 20% yield of the title compound. MS(ES)=437(+NH3)

Workup

  1. temperatureheat under reflux conditions for 14 hours
  2. customAcidify with 1N HCl and collect the solid
  3. filtrationby filtration
  4. customdry
  5. customPurify by reverse phase HPLC

Sources & evidence

ORD record
ord-ade230707e7e41ffaed77f958ed53702
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

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