Butanal → 2-{4-[2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]piperazin-1-ylmethyl}cyclopropanecarboxylic acid ethyl ester

Participants

Reaction Steps

1-[2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]piperazine (2.1 g, 7 mmol) produced in Example (8b) was used as a starting material. Reaction was conducted in a manner similar to Example (4g), using 2-formyl-1-cyclopropanecarboxylic acid ethyl ester (cis/trans mixture, predominantly trans) instead of butyraldehyde, and similar treatment was carried out to give 2.4 g of 2-{4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazin-1-ylmethyl}cyclopropanecarboxylic acid ethyl ester as a colorless oil.

Provenance & Evidence