反应详情

To a solution of 1-butyl-4-[5-fluoro-2-(3,3,5,5-tetramethylcyclohex-1-enyl)phenyl]piperidine hydrochloride (47 mg, 0.12 mmol) produced in Example (106h) in methanol (3 mL) was added 10% palladium on carbon (100 mg, wet), followed by stirring for 4 hours at atmospheric pressure and room temperature under a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure. Hexane was added to the residue to produce a solid, which was then triturated by sonication. The solid was filtered and dried under reduced pressure to give 19 mg of the title compound as a light yellow solid.

1. filtrationThe reaction mixture was filtered through Celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionHexane was added to the residue
4. customto produce a solid, which
5. customwas then triturated by sonication
6. filtrationThe solid was filtered
7. customdried under reduced pressure