Formamide → 6,7-Dimethoxy-3H-quinazolin-4-one

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-amino-4,5-dimethoxybenzoic acid (9.9 mg, 0.050 mmol) and formamide (5 ml) was heated at 190° C. for 6 hours. The mixture was cooled to 80° C. and poured onto water (25 ml). Precipitated material was filtered off, washed with water and dried in vacuo. Yield 1.54 g (15%), brown powder. The structure was confirmed by 1H (500 MHz) and 13C NMR (125 MHz) analysis.

Provenance & Evidence