Methyl acetoacetate → 2-Cyclohexyl-5-methyl-2,4-dihydro-pyrazol-3-one

Participants

Reaction Conditions

Reaction Steps

Cyclohexylhydrazine hydrochloride (2.00 g, 13.3 mmol) and methyl acetoacetate (2.37 g, 20.4 mmol) were combined in glacial acetic acid (55 mL). The reaction was heated to 100° C. for 18 h. After allowing the reaction to cool to RT, the solvent was removed under reduced pressure to give 2.46 g of the desired product as a pale orange solid. This material was used without further purification. MS (ES+) m/z 181.2 (M+H+).

Provenance & Evidence