Sodium Bicarbonate → HCID 178527290, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[4-amino-3- (2-chloroethoxy)-5-(naphthalene-1-sulfonylmethyl)phenoxy]ethanol (1.22 g, 2.8 mmoles) in THF and 4M HCl was stirred, under nitrogen, at 3° C., treated dropwise with a solution of sodium nitrite (0.20 g, 2.94 mmoles) in H2O, poured into a cold solution of saturated sodium bicarbonate and extracted with EtOAc. The extracts were combined, dried over Na2SO4 and concentrated under vacuum to afford the title compound (1.18 g, 2.65 mmoles), identified by HNMR and mass spectral analyses.

Provenance & Evidence