HCID 86619925, compound → HCID 59718699, compound

Participants

Reaction Steps

In an analogous procedure to that described in Example 8d), the hydrogenolysis of the first eluting epimer (R or S)-(−)-N-[(S)-1-(2-benzyloxy-ethyl)-2-oxo-5-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-hydroxy-2-methyl-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide using palladium on carbon (10%) as the catalyst yielded the title compound as a white foam (yield 75% of theory); MS (m/e): 551 (M+H)+.

Provenance & Evidence