反应详情

A solution of methyl(benzyloxy)acetate (1 eq) and dimethyl oxalate (1.2 eq) in dry THF was cooled to −78° C. and LDA (2M in THF-heptane, 1.2 eq) was added dropwise. After stirring for an hour the cold bath was removed, and stirring was continued for an additional hour. The reaction was quenched at 0° C. by pouring into cold 1N aq HCl, and the aqueous phase was extracted with EtOAc; the organic layer was washed with brine, dried and concentrated to give a crude that was used without further purification.

1. customwas removed
2. stirringstirring
3. waitwas continued for an additional hour
4. customThe reaction was quenched at 0° C.
5. additionby pouring into cold 1N aq HCl
6. extractionthe aqueous phase was extracted with EtOAc
7. washthe organic layer was washed with brine
8. customdried
9. concentrationconcentrated
10. customto give a crude that
11. customwas used without further purification