HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 59771033, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 67147606 | HCID 67147606 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59771033 | HCID 59771033 | — |
Reaction Steps
A solution of crude N-(4-fluorobenzyl)-3-hydroxy-8-(methylamino)-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 1-hydroxybenzotriazole (2 eq.), 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (2 eq.), DIPEA (1 eq.) and acetic acid (2 eq) in dichloromethane was stirred for 16 h at room temperature. The solvent was removed under vacuum and the product was isolated by prep. RP-HPLC, using water (0.1% TFA) and acetonitrile (0.1% TFA) as eluents (column: C18). After lyophilization the product was obtained as a fluffy white material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414045B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-b5738f881f974fc2895fd56cd51ec079 |
| Source note | uspto-grants-2008_08 |