Sulfuric Acid → 61706-47-6

HRID 2219082Notes

Reaction equation

HRID 2219082 reaction equation
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([CH3:11])[C:9]#[N:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].S(=O)(=O)(O)[OH:21].[OH-].[Na+]>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)([CH3:11])[C:9]([NH2:10])=[O:21])=[CH:18][CH:19]=1)([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 2110592-(4-Nitrophenyl)-2-phenylpropanenitrile

Product 1

HCID 304617961706-47-6

Procedure

) A mixture of 0.020 mol of p-nitro-α-phenylhydratroponitrile and 28 ml of concentrated sulfuric acid solution (90%) is heated in a water-bath for 3.5 hours. The reaction mixture is poured onto crushed ice, neutralized with a sodium hydroxide solution and the product is extracted with chloroform. The organic layer is washed with water, dried and evaporated in vacuo and the residue is crystallized from ether, yielding 2.4 grams of p-nitro-α-phenylhydratropamide. (interm. 7)

Workup

  1. temperatureis heated in a water-bath for 3.5 hours
  2. additionThe reaction mixture is poured
  3. customonto crushed ice
  4. extractionthe product is extracted with chloroform
  5. washThe organic layer is washed with water
  6. customdried
  7. customevaporated in vacuo
  8. customthe residue is crystallized from ether

Sources & evidence

ORD record
ord-84c90870540c4400978c5e456b8b41ca
Source dataset
uspto-grants-2008_08
Patent number
US07414048B2

Reaction notes

Loading…