Triphenylphosphine → HCID 10098703, compound

Participants

Reaction Steps

1.69 g of azadicarboxylic acid diisopropyl ester are added dropwise at 0-5° C. to a solution of 1.97 g of triphenylphosphine in 60 ml of THF. After 30 minutes at 0-5° C., 2.5 g of 3-[2,6-dichloro-4-(3,3-dichloroallyloxy)-phenoxy]-propan-1-ol and 1.5 g of (4-hydroxy-phenyl)-carbamic acid tert-butyl ester dissolved in 30 ml of tetrahydrofuran are added dropwise. After being stirred for 24 hours at room temperature, the reaction mixture is concentrated and then purified over silica gel. (4-{3-[2,6-Dichloro-4-(3,3-dichloroallyloxy)-phenoxy]-propoxy}-phenyl)-carbamic acid tert-butyl ester (compound 1.6) is obtained.

Provenance & Evidence