Bromoacetonitrile → HCID 86610928, compound

HRID 2219210Notes

Reaction equation

[CH2:1]([C:8]1[CH:35]=[CH:34][CH:33]=[CH:32][C:9]=1[O:10][CH2:11][CH2:12][CH2:13][NH:14][CH:15]([C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=1)[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:37][C:38]#[N:39]>>[CH2:1]([C:8]1[CH:35]=[CH:34][CH:33]=[CH:32][C:9]=1[O:10][CH2:11][CH2:12][CH2:13][N:14]([CH2:37][C:38]#[N:39])[CH:15]([C:24]1[CH:25]=[CH:26][C:27]([O:30][CH3:31])=[CH:28][CH:29]=1)[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 69275238HCID 69275238, compound

Product 1

HCID 86610928HCID 86610928, compound

Procedure

By following similar procedure as described in Preparation 93, N-alkylation of [3-(2-benzyl-phenoxy)-propyl]-[bis-(4-methoxy-phenyl)-methyl]-amine with bromoacetonitrile gives the title compound as oil. FABMS: m/z 506 (M)+, 507 (M+H)+.

Sources & evidence

ORD record: ord-c26f745fa0c0436f823c90f639e7121f
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414063B2

Reaction notes

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