Methyl iodide → HCID 69275118, compound

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Reaction Steps

Powdered K2CO3 (50.4 mg, 0.365 mmol) is added to a stirred solution of [2-(2-benzyl-phenoxy)-ethyl]-[2-(isoquinoline-5-sulfonylamino)-ethyl]-carbamic acid tert-butyl ester (82.0 mg, 0.146 mmol) and CH3I (18.2 μL, 0.292 mmol) in anhydrous DMF (1 mL) at ambient temperature under nitrogen. The resultant solution is stirred for 2 hours. The mixture is diluted with EtOAc (10 mL), washed with water (5 mL×3), dried over MgSO4, filtered and concentrated. The crude product is chromatographed on silica (gradient 0-5% CH3OH in CH2Cl2) to give 65 mg (0.11 mmol, 77% yield) of the title compound as a gum. ESIMS: m/z 576 (M+H)+.

Provenance & Evidence